![]() ![]() ![]() Cancer-associated fibroblasts were activated by the melanoma cell-produced exosomes significantly more than their normal counterparts, as assessed by increased transcription of genes for inflammation-supporting cytokines and chemokines, namely IL-6 or IL-8. We have focused on potential differences in the activity of exosomes produced by melanoma cells towards melanoma-associated fibroblasts and normal dermal fibroblasts. ![]() Importantly, melanoma cell-produced exosomes represent an important tool of intercellular communication within this cancer ecosystem. Similarly to other types of tumours, the cancer microenvironment plays a prominent role and determines the biological properties of melanoma. This requires identification of novel therapeutic targets in melanoma. While the treatment of initial stages of the disease is simple, the advanced disease frequently remains fatal despite novel therapeutic options. The incidence of cutaneous malignant melanoma is increasing worldwide.
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